What are the storage precautions for polypropylene glycol PPG?


Date:

2022-05-13

Polypropylene glycol (PPG) is a colorless to yellow viscous liquid containing polymer, with the Molecular formula of H (C3H6O) NaOH and molecular weight of 400~2000. Not easily volatile. Non corrosive. Its monoester is a non ionic surfactant that can also react with alcohols to form ethers. It is a solvent for vegetable oil, resin, and paraffin. It can also be used to prepare alkyd resins, emulsifiers, demulsifiers, lubricants, and plasticizers.

  

聚丙二醇PPG

 

Storage of Polypropylene Glycol PPG:

It should be packaged in clean, dry, sealed, and leak free iron drums. Store away from sunlight, rain, and sources of ignition. Due to its hygroscopicity, do not come into direct contact with air. Avoid open flames and prolonged heating in the air. Especially for insulation materials and clothing infiltrated by polyether polyols, they often catch fire naturally and should be noted. This product is not limited by the storage rules for flammable liquids, but it should be avoided from entering groundwater or surface water as it is not easily biodegradable. When overflowing, cover it with permeable substances such as sawdust, yellow sand, cloth, etc., shovel it to the garbage collection area, remove it from the workplace, and then carry out sewage treatment. For example, fire, foam, dry powder, dry ice, water, etc.

Synthesis method of polypropylene glycol PPG:

1. Glycerol is polymerized under the catalysis of potassium hydroxide at 90~95 ℃ and 0.4~0.5MPa pressure. Then cool it to 60~70 ℃, press the material into the neutralization kettle, stir and add water to neutralize the surplus potassium hydroxide, then add phosphoric acid at 60~70 ℃ to neutralize it to pH 6~7, then slowly heat it to 110~120 ℃, vacuum dehydration and filtration.

2 is formed by the Addition reaction of propylene glycol polymer and water.

In the production of peptides, proteins and other types of drugs, many macromolecules will produce a large number of foam. If not eliminated in a timely manner, it will bring many adverse effects to the production process, equipment, and product quality. Defoamer is an additive widely used in the production process to eliminate and inhibit foam. Compared with mechanical defoamer, defoamer has more significant defoaming effect and efficiency. Commonly used defoamers include polyether, silicone, mineral oil, etc.

Due to the unique nature of drugs, the regulation of biopharmaceutical technology is becoming increasingly strict. Therefore, the requirements for the type, dosage, and residue detection of additives in drug production are becoming increasingly high. Propylene glycol is a widely used non ionic surfactant. Propylene glycol derivative defoamers are widely used in industries such as food and fermentation. It has the characteristics of low toxicity, small dosage, and good defoaming effect. In order to effectively detect trace amounts of defoamer residues and control the quality of drug production processes, high-precision and efficient detection methods are needed. Polypropylene glycol PPG

After years of technological research and experience accumulation, microsource detection has developed a liquid chromatography-mass spectrometry (LC-MS) method for detecting residual propylene glycol defoamers in drugs. Due to the relatively high molecular weight and weak UV response of propylene glycol, liquid chromatography was chosen, using methanol and water as mobile phases and mass spectrometry to accurately locate propylene glycol. The laboratory validated the method and the results showed that all indicators were within an acceptable range, with a quantification limit of 0.1 μ G/ml, suitable for the detection of propylene glycol defoamers in drugs. For other types of defoamer residues, you can review your previous experience sharing or welcome to communicate in the comments section.